If you have diabetes and already have cardiovascular disease or a 10-year increased risk of heart attack, aggressive statin therapy may be one of the best things you can do to help prevent a heart attack or stroke.© 2005-2020 Healthline Media a Red Ventures Company. While Actos is a diabetes medicine that can help lower blood sugar, research studies also show that there are lipid lowering effects with Actos. Each person has different individual health factors that determine their risk for developing heart disease.

Talk to your doctor to see if a change of dosage or even a different type of medication might be helpful.One of the most common complaints of people taking statins is muscle pain.

Several guidelines exist and statin use is expected to increase with the new cholesterol guidelines bringing along new challenges for prescribers. Don’t worry we won’t send you spam or share your email address with anyone. A "nocebo" effect means people who have negative expectations about a medication report experiencing the potential side effect at higher rates than the drug should cause.The actual risk of developing muscle pain as a result of taking statins is about 5 percent or less compared with taking a pill that doesn't contain medication (placebo). Our website services, content, and products are for informational purposes only.

When your blood vessels are damaged, blood flow to the heart and brain can be disrupted. Statins are one of the most widely prescribed drug classes in Europe for lipid control and cardiovascular prophylaxis, and prescribing is continuing to grow. Search for other works by this author on: Search for other works by this author on: As demonstrated in Demographic and clinical variables in all participants and stratified by hydrophilic and lipophilic statin useAbbreviations: AAC, abdominal aortic calcification; BMI, body mass index; HOMA, homeostasis model assessment; IQR, interquartile range. Insulin resistance was greater in hydrophilic statin users compared to lipophilic statin users.
Don't stop taking your statin medication before talking to your doctor. This may restrict generalizability to other groups. Lancet 2008; 371: 117–25. They then used accepted statistical methods to pool these results to see if the risk of diabetes or cardiovascular events differed between intensive-dose and moderate-dose statins. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.

In studies, people using the drug for type 2 diabetes also appeared to have higher HDL cholesterol and lower triglyceride levels.

Search for other works by this author on: AbstractContext. Myalgia is a commonly reported adverse effect of statins, but placebo-controlled trial data do not support the conclusion that statin use has a … They include There are no longer specific levels of “good” and “bad” cholesterol that everyone should have to be considered healthy. First, the pleiotropic actions of statins may differ based on the lipophilicity versus the hydrophilicity of the particular statin drug [Statin drugs have not consistently shown a similar level of cardiovascular benefit in patients with low kidney function, and an increased risk of stroke was observed to be associated with statins in 1 large, well-conducted, randomized, controlled trial [Our primary objective was, firstly, to evaluate the association between statin use and insulin resistance assessed by the homeostasis model assessment (HOMA-IR) in nondiabetic participants at year 10 from the Kingston center of the population-based observational Canadian Multicenter Osteoporosis Study (CaMos) [Statin use and specific type was assessed by direct interview at year 10 (2005–2007) in CaMos participants of the Kingston site. Talk to your doctor if you have concerns.The FDA warns on statin labels that some people have developed memory loss or confusion while taking statins.

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The number of participants on a statin in each strata used in the PS analysis varied from 7–8 for the HOMA-IR and 11–12 for the AAC assessment.Demographic, clinical variables, HOMA, and AAC at year 10 in CaMos participants at the Kingston site overall and stratified by statin useNote: Kruskal-Wallis test comparing statin users and nonstatin users.Abbreviations: AAC, abdominal aortic calcification; BMI, body mass index; CaMos, Canadian Multicentre Osteoporosis Study; HOMA, homeostasis model assessment; IQR, interquartile range. If the results were very different, this would suggest that the studies might be too different to be pooled in this way. Result sets returned from queries were exported as csv files and imported into SAS.SAS version 9.4 (SAS Institute, Inc., Cary) for Windows was used for the statistical analysis and an α level of 0.05 was used to indicate statistical significance. All rights reserved.