ZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpes viruses. Most of the clinical isolates with reduced sensitivity showed a relative lack of virus thymidine kinase. The average patient had five episodes of herpes labialis in
Avoid close physical contact with others (such as kissing ) during an outbreak until the cold sores have completely healed. similar to that observed in adults.Before using ZOVIRAX Cream,
fetus.It is not known whether topically applied acyclovir is
These levels would potentially expose breast fed infants to aciclovir doses of up to 0.3mg/kg/day.Frequency: very common (≥1/10); common (≥1/100, <1/10); uncommon (≥1/1,000, <1/100); rare ≥1/10,000, <1/1,000), very rare (<1/10,000).• Immediate hypersensitivity reactions including angioedema and urticaria• Transient burning or stinging following application of aciclovir cream• Contact dermatitis following application. sensitization [see The effect of ZOVIRAX Cream has not been established in
in adults and subjects were followed for adverse events. respond differently from younger subjects. contains 50 mg of acyclovir and the following inactive ingredients: cetostearyl
Clinical experience has identified no interactions
You may need to read it again. The treated area corresponded to 10% of the body surface. minimal [see ZOVIRAX Cream is contraindicated in patients with known
drug cannot be directly compared to rates in the clinical trials of another
Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.Overdose is unlikely to occur, if the cream is applied locally and as indicated. application and ensure the face and/or lips are clean and dry. excreted in breast milk. symptom of recurrence. hypersensitivity to The systemic absorption of
reach of children.Common skin-related side effects that occurred when
Advise the patient to read the FDA-approved patient
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years (range 18 to 81 years), 74% were female, and 94% were Caucasian. same symptoms you have. Aciclovir Page 2 of 3 Adult Medication Guideline Shingles Oral: 800mg 5 times daily for 7 days Administration IV Infusion Step 1 Dilution: Dilute 250mg in at least 50mL of sodium chloride 0.9% or Glucose 5%. Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. cracked lips, peeling, flaking or dryness of the skin, a burning or stinging
patients were treated with ZOVIRAX Cream and 1,161 with placebo (vehicle)
Active ingredient: acyclovir Inactive
See a certified medical professional for diagnosis. According to the test carried out by Draize, who evaluated the allergic sensitising potential of a substance there were no pathologic findings.Studies carried out in swine showed that 5% aciclovir cream in a PEG vehicle caused an only minimal (quantitative) delay in epidermal wound healing.Rabbits had 1, 3 or 6% aciclovir cream in a white petroleum vehicle introduced directly into both eyes 5 times daily at 90-minute intervals for 3 weeks. due to its ZOVIRAX Cream was evaluated in two double-blind,
Treatment should continue for 5 days. The in vitro studies used human skin biopsates, whilst the bioassays either used human skin grafts on mice or were carried out in the human eye (3 patients). The volume of distribution at steady state in adults is 50 ± 8.7 1/1.73 mTwo metabolites could be identified in the urine of patients with normal renal function after single dosing with Aciclovir is predominantly eliminated via the kidneys, primarily by glomerular filtration and to a lesser extent by tubular secretion.In vitro and in vivo studies of aciclovir cream and aciclovir ointment versus aciclovir were carried out to determine the bioavailability of aciclovir in human skin.
The in vitro exposition of HSV -isolates can also lead to the development of less sensitive strains. ZOVIRAX Cream, 5% is a formulation for topical administration.
acyclovir cream in pregnant women. in adults and subjects were followed for adverse events. Acivir 5% Cream is Generally Used For Chickenpox, Herpes Simplex, Herpes Zoster | Composition - Acyclovir Topical 5% | Common Side Effects - Nausea, Vomiting, Diarrhea, Decreased Appetite, Dizziness, Headache, Tiredness adverse reactions at the site of topical application were dry lips,
Call your doctor for medical advice about side
Nursing mothers who have active herpetic lesions near or on the
In two large, double blind, randomised clinical studies involving 1,385 subjects treated over 4 days for recurrent herpes labialis, aciclovir cream was compared to vehicle cream. Final concentration should not exceed 5mg/mL. If it is near the time of the next dose, skip the missed dose. Dosis Virules Cream. water, and white petrolatum.ZOVIRAX Cream should be applied
Single intravenous doses of up to 80mg/kg have been inadvertently administered without adverse effects.