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Motor function should be assessed at different times of the day, such as when drugs are reaching peak therapeutic levels (i.e., 30–60 min after oral dose), as well as when drug effects are minimal (just before the next dose).Document increased motor side effects such as involuntary movements (dyskinesias), increased muscle tone, fluctuations in response (on-off phenomenon, end-of-dose akinesia), or other abnormal movement patterns (extrapyramidal syndrome). OLANZapine is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. Genetic Implication. Document orthostatic hypotension and contact physician when systolic BP falls >20 mm Hg, or diastolic BP falls >10 mm Hg.If used to treat restless leg syndrome, assess the severity and frequency of restless episodes (i.e., an intense need to get up and move around) and lower extremity symptoms such as crawling, tingling, cramping, aching, burning, creeping, and similar sensations.