Cefpodoxime controls the growth of bacteria and kills them by inhibiting the synthesis of bacterial cell wall. Do not self medicate, as this antibiotic is for severe infections. Take the tablet with food; the suspension can be taken with or without food. If your pet is on any aminoglycosides (gentamicin or If you suspect or know you dog has had an overdose, please contact your veterinarian, an emergency vet clinic, or the Pet Poison Helpline at (855) 213-6680 immediately. It is usually taken every 12 hours for 5 to 14 days depending on the condition being treated. Missed doses reduce the effectiveness of therapy. Usual doses of cefpodoxime are as follows, but they are intended as a guide only. In case of a missed dose, give it as soon as you remember. Do not take a double dose to make up for a missed one. Simplicef (generic name cefpodoxime proxetil) is an antibiotic veterinarian medication of the cephalosporin class, used to treat various infections caused by gram-positive and gram-negative bacteria. Ensure entire course of treatment is administered so the infection does not recur or worsen. Do not give two doses at one time.Dogs may also experience drooling, rashes and excitability, while cats may also experience vomiting, rashes and a fever greater than 103 degrees Fahrenheit. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location â one that is up and away and out of their sight and reach. The liquid may be taken with or without food. If the dose is close to the next dose, skip the dose you missed and resume your regular schedule. See the FDA's Safe Disposal of Medicines website (It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. If the dose is close to the next dose, skip the dose you missed and resume your regular schedule. If a dose of Cefpodoxime Proxetil is missed, give it as soon as you remember. It is usually taken every 12 hours for 5 to 14 days depending on the condition being treated.