Teratogenicity including increased incidence of cleft palate have occurred in animal studies, however, the relevance to human has been questioned. Dexamethasone injection is also used to treat certain conditions that affect the blood, skin, eyes, thyroid, kidneys, lungs, and nervous system. Maternal pulmonary edema has been reported with inhibition of uterine contractions and fluid overload. Dexamethasone may be given to women at risk of delivering prematurely to promote maturation of the fetus' lungs. Select one or more newsletters to continue. Eye drops, or suspension-drops, in some cases, it is allowed to drip into the nasal cavity - for example, during sinusitis, rhinopharyngitis, pollinosis. This administration, given from day to one week before delivery, has been associated with low birth weight, although not with increased rates of neonatal death. Corticosteroids appear in breast milk in low amounts; specific information on this drug is unknown. Conclusion: Dexamethasone accelerates maturation of fetal lungs, decrease number of neonates with respiratory distress syndrome and improves survival in preterm delivered neonates. Dexamethasone was used in the Recovery Trial in oral (liquid or tablets) or intravenous preparation 6 mg once daily for ten days. If you have ever had an unwanted blood clot in an artery or a vein. The value of test of proportion was z = 2.85 (p < 0.05), between control group and group consists of the pregnant women received dexamethasone for five days. Dexamethasone is commonly given as a treatment for Dexamethasone may be administered before antibiotics in cases of Dexamethasone is also used as a direct chemotherapeutic agent in certain Dexamethasone is the treatment for the very rare disorder of glucocorticoid resistance.Dexamethasone may be given to women at risk of delivering prematurely to promote Dexamethasone has also been used during pregnancy as an A small clinical trial found long-term effects on verbal working memory among the small group of children treated prenatally, but the small number of test subjects means the study cannot be considered definitive.Intravenous dexamethasone is effective for prevention of nausea and vomiting in people who had surgery and whose post-operative pain was treated with long-acting spinal or epidural spinal opioids.Dexamethasone, when used as an anti emetic during surgery, does not appear to increase rates of wound infection and it is unclear if it has an effect on wound healing.A single dose of dexamethasone or another steroid speeds improvement of a The exact incidence of the adverse effects of dexamethasone are not available, hence estimates have been made as to the incidence of the adverse effects below based on the adverse effects of related corticosteroids and on available documentation on dexamethasone.Sudden withdrawal after long-term treatment with corticosteroids can lead to:To synthesize dexamethasone, 16β-methylprednisolone acetate is O=C(CO)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]1(C(=CC(=O)C=C1)CC[C@H]4[C@@H]2C[C@H]3C)C)CInChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1Dan L. Longo, Anthony Fauci, Dennis Kasper, Stephen Hauser, J. Jerry Jameson and Joseph Loscalzo, There are no adequate and well controlled studies in pregnant women. There is the possibility of adrenal cortex suppression in the newborn with long term use in the mother; however, the short term use of corticosteroids antepartum for the prevention of respiratory distress syndrome does not seem to pose a risk to the fetus or the newborn infant. Theoretically, its presence in breast milk could suppress growth, interfere with endogenous corticosteroid production, or cause other unwanted effects in breast fed babies.