WebMD does not provide medical advice, diagnosis or treatment. This eMedTV Web page discusses these and other potential drug interactions associated with pantoprazole, such as those involving ketoconazole. No formal drug interaction studies of high-dose methotrexate with PPIs have been conducted [see Warnings and Precautions (5.12)]. Close monitoring is recommended in patients with diarrhea and in those taking antibacterial agents as CDAD has been reported with the use of nearly all these agents. Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, … The aim of this article is to apprise practitioners of a new labeling change based on the accumulating evidence for a possible drug-drug interaction between methotrexate (primarily at high doses) and proton pump inhibitors (PPIs). Eur J Gastroenterol Hepatol. The risk was increased in patients who received high doses (multiple daily doses), and long term treatment (a year or longer). It is recommended that patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated. In the drug interaction studies conducted so far, pantoprazole did not affect the pharmacokinetics or pharmacodynamics of antipyrine, diazepam, digoxin, a hormonal contraceptive, nifedipine, phenytoin, theophylline and warfarin in man.

Small effects on CYP reported fo … Omeprazole, lansoprazole and pantoprazole are all mainly metabolised by the polymorphically expressed cytochrome P450 (CYP) isoform CYP2C19 (S-mephenytoin hydroxylase).
This copyrighted Intervention: A temporary withdrawal of Pantoprazole sodium delayed-release tablets may be considered in some patients receiving high-dose methotrexate. Background: A number of medications are known to interact with methotrexate through various mechanisms. Swallow the tablets whole. Drug interactions and 106 reactions for Pantoprazole. 1996 Oct;8 Suppl 1:S21-5. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated.Moderate Potential Hazard, Low plausibility. that use of a particular drug is safe, appropriate or should be consulted before taking any drug, changing any diet material has been downloaded from a licensed data The risk of side effects goes up over time. Meyer UA. Enter your medication into the WebMD interaction checker We comply with the HONcode standard for trustworthy health information - This diagnosis should be considered for diarrhea that does not improve.

Continue to take this medication for the prescribed length of treatment even if you are feeling better.Tell your doctor if your condition persists or worsens. Severe Interactions. In patients with mild to moderate hepatic impairment, little drug accumulation has been observed following once-daily, multiple-dose administration. To help you remember, take it at the same time each day.

Severe Interactions. Pantoprazole has moderate interactions with at least 52 different drugs. Formal drug interaction studies have not revealed any clinically significant interactions between pantoprazole and other agents. All 3 proton pump inhibitors have a very limited potential for drug interactions at the CYP level. Use WebMD’s Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. This information does not contain all possible interactions or adverse effects. A healthcare professional Patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated.

The information is not intended to cover all possible Do not double the dose to catch up.Store at room temperature away from light and moisture. is intended to supplement, not substitute for, the Regular monitoring is recommended.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
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Applies to: Magnesium ImbalanceSymptomatic and asymptomatic hypomagnesemia has been reported rarely in patients treated with PPIs for at least 3 months, in most cases after a year of therapy.

For people taking pantoprazole, drug interactions may occur with warfarin and ampicillin esters.