Metoprolol Versus Carvedilol in Patients With Heart Failure, Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, and Renal Failure. Rationale and design of the carvedilol or metoprolol European trial in patients with chronic heart failure: COMET. doi: 10.1016/s0735-1097(01)01471-1. 1. Clipboard, Search History, and several other advanced features are temporarily unavailable. doi: 10.1016/j.amjcard.2019.12.048. Besides the succinate formulation, metoprolol tartrate has also been compared with carvedilol in small prospective trials and retrospective analyses of heart failure databases.

2015 Apr 15;115(8):1111-5. doi: 10.1016/j.amjcard.2015.01.545.

Please enable it to take advantage of the complete set of features!

Published by Elsevier Inc. 2015 Apr 15;115(8):1111-5. doi: 10.1016/j.amjcard.2015.01.545. doi: 10.1016/j.amjcard.2019.12.048. 2004 Apr;9(2):131-7. doi: 10.1023/B:HREV.0000046368.08825.20.Li H, Duan Y, Chen B, Zhao Y, Su W, Wang S, Wu J, Lu L.Medicine (Baltimore).

1999 Nov 1;34(5):1522-8. doi: 10.1016/s0735-1097(99)00367-8.Congest Heart Fail. Epub 2013 Jan 4. Objectives: This study investigates the effects of a change of beta-adrenergic blocking agent treatment from metoprolol to carvedilol and vice versa in patients with heart failure (HF). 1 Current recommendation of beta blockers in patient with HF include bisoprolol, carvediol, or metoprolol succinate. The data supports the need for furthering testing to determine optimal choice of beta blockers in patients with heart failure with reduced ejection fraction. A study performed by Fauchier et al. Of 7058 patients enrolled in the OBTAIN prospective multi-center registry of patients 2014 Oct;174(10):1597-604. doi: 10.1001/jamainternmed.2014.3258.Fröhlich H, Zhao J, Täger T, Cebola R, Schellberg D, Katus HA, Grundtvig M, Hole T, Atar D, Agewall S, Frankenstein L.Circ Heart Fail. 2014 Oct;174(10):1597-604. doi: 10.1001/jamainternmed.2014.3258.Fröhlich H, Zhao J, Täger T, Cebola R, Schellberg D, Katus HA, Grundtvig M, Hole T, Atar D, Agewall S, Frankenstein L.Circ Heart Fail. Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Carvedilol is more commonly used in heart failure or high blood pressure (hypertension) whereas metoprolol is used in angina and/or after a heart attack.

JAMA Intern Med. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2016 Feb;95(5):e2427. The adjusted hazard ratio of mortality for metoprolol succinate compared to carvedilol was 1.069 (95% CI: 1.046-1.092, P value: < .001).

Epub 2015 Jan 31.DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, O'Keefe JH.Am J Cardiol.

2015 Sep;8(5):887-96. doi: 10.1161/CIRCHEARTFAILURE.114.001701.

doi: 10.1097/MD.0000000000002427.JAMA Intern Med.

For statistically significant associations, a conditional inference tree was used to assess predictors most associated with the outcome.

Am J Cardiol. Epub 2018 Jun 21.JAMA Intern Med.

Unable to load your collection due to an error COVID-19 is an emerging, rapidly evolving situation. Copyright © 2020 Elsevier Inc. All rights reserved. Elsevier Science Beta-blockers (BB) are uniformly utilized post-myocardial infarction (MI), but no specific BB is recommended and there are no direct comparisons of metoprolol (M) and carvedilol (C), two commonly prescribed BB.

Administration of metoprolol has been shown to cause up-regulation of beta-adrenoceptor density and to decrease nocturnal melatonin release, whereas carvedilol lacks these typical effects of beta-blocking drugs. Elsevier Science 2013 Aug;34(29):2271-80. doi: 10.1093/eurheartj/ehs433.

Elsevier Science

2013 Nov;108(6):384. doi: 10.1007/s00395-013-0384-7.

Am J Cardiol. 2018 Sep 15;122(6):994-998. doi: 10.1016/j.amjcard.2018.05.038. This site needs JavaScript to work properly. Metra M, Nodari S, D'Aloia A, Muneretto C, Robertson AD, Bristow MR, Dei Cas L.J Am Coll Cardiol. 2. Comparing carvedilol and metoprolol: results of the COMET trial. Carvedilol (Coreg) and metoprolol tartrate (Lopressor, Toprol XL) are beta-adrenergic blocking agents (beta-blockers) used to treat high blood pressure (hypertension) and congestive heart failure.