Name must be less than 100 characters Dutasteride inhibits 5α-reductase isoenzymes type 1 and 2 better than finasteride, leading to a more complete reduction in DHT at 24 weeks (94.7% versus 70.8%).
Scalp skin biopsies were obtained before and after treatment for measurement of T and DHT by high pressure liquid chromatography-RIA.
In this study, male subjects treated with 5 mg/day finasteride for 4 weeks had significantly decreased concentrations of DHT in bald scalp, resulting in a mean level similar to the baseline levels found in hair-containing scalp.
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Finasteride (17 beta-N-tert-butylcarbamoyl-4-aza-5 alpha-androstan-1-en-3- one) is a time-dependent, apparently irreversible inhibitor of 5 alpha-reductases, but does not fully inhibit the activity of 5 alpha-reductase in vivo.
5-alpha reductase inhibitors (dutasteride and finasteride) are generally well tolerated. 2020 Jan 23;10:1528. doi: 10.3389/fphar.2019.01528. Their role as chemopreventive agents for prostate cancer is also under investigation.
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doi: 10.1097/00042307-200301000-00006. 5-alpha reductase inhibitors are drugs that treat benign prostatic hyperplasia, also called enlarged prostate. 2002 Sep;41(5):412-24. doi: 10.1007/s00120-002-0230-2.Expert Opin Pharmacother. Drugs in …
2005 Feb;6(2):311-7. doi: 10.1517/14656522.214.171.1241.Jiwrajka M, Yaxley W, Ranasinghe S, Perera M, Roberts MJ, Yaxley J.Aust Prescr. Unable to load your delegates due to an error
The scalp of men with androgenetic alopecia (male-pattern baldness) has also been fou…
Clipboard, Search History, and several other advanced features are temporarily unavailable. 2002 Apr;19(6):413-25. doi: 10.1007/s00345-002-0248-5.Eur Urol. Unable to load your delegates due to an error 2015 Nov;80(5):1208-18. doi: 10.1111/bcp.12671.
2020 Jul;38(3):323-337. doi: 10.5534/wjmh.200012.
Epub 2020 Mar 20.Drug Des Devel Ther. Epub 2015 Mar 20.J Med Food.
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Epub 2012 Apr 17. 5-alpha-reductase (5AR) is an enzyme in the body that converts testosterone into DHT which then goes on to cause hair loss in men affected with androgenic alopecia. Br J Dermatol.
2006 Apr;154(4):730-4. doi: 10.1111/j.1365-2133.2005.07072.x.Drake L, Hordinsky M, Fiedler V, Swinehart J, Unger WP, Cotterill PC, Thiboutot DM, Lowe N, Jacobson C, Whiting D, Stieglitz S, Kraus SJ, Griffin EI, Weiss D, Carrington P, Gencheff C, Cole GW, Pariser DM, Epstein ES, Tanaka W, Dallob A, Vandormael K, Geissler L, Waldstreicher J.Schwartz JI, Tanaka WK, Wang DZ, Ebel DL, Geissler LA, Dallob A, Hafkin B, Gertz BJ.J Clin Endocrinol Metab. By inhibiting the enzyme we can essentially slow down the production of DHT and thereby prevent hair loss.